CAR T Cells Contend with Myeloma in the Bone Marrow Microenvironment.
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ABSTRACT:
SUBMITTER: Graham CE
PROVIDER: S-EPMC9777257 | biostudies-literature | 2022 Nov
REPOSITORIES: biostudies-literature
Publications
CAR T Cells Contend with Myeloma in the Bone Marrow Microenvironment.
Graham Charlotte E CE Maus Marcela V MV
Blood cancer discovery 20221101 6
In this issue of Blood Cancer Discovery, Dhodapkar and colleagues find that myeloid, dendritic, and endogenous T-cell populations in the bone marrow microenvironment are associated with progression-free survival (PFS) in multiple myeloma patients responding to B-cell maturation antigen-targeted CAR T cells. Immunosuppressive myeloid cells are associated with short PFS, but a diverse T-cell receptor repertoire and more dendritic cells are associated with a longer PFS, suggesting a potential role ...[more]
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