MST4: A Potential Oncogene and Therapeutic Target in Breast Cancer.
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ABSTRACT:
SUBMITTER: Arora R
PROVIDER: S-EPMC9777386 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Publications
MST4: A Potential Oncogene and Therapeutic Target in Breast Cancer.
Arora Ritu R Kim Jin-Hwan JH Getu Ayechew A AA Angajala Anusha A Chen Yih-Lin YL Wang Bin B Kahn Andrea G AG Chen Hong H Reshi Latif L Lu Jianrong J Zhang Wenling W Zhou Ming M Tan Ming M
Cells 20221215 24
The mammalian STE 20-like protein kinase 4 (MST4) gene is highly expressed in several cancer types, but little is known about the role of MST4 in breast cancer, and the function of MST4 during epithelial-mesenchymal transition (EMT) has not been fully elucidated. Here we report that overexpression of MST4 in breast cancer results in enhanced cell growth, migration, and invasion, whereas inhibition of MST4 expression significantly attenuates these properties. Further study shows that MST4 promote ...[more]
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