Genetics in Idiopathic Pulmonary Fibrosis: A Clinical Perspective.

ABSTRACT:

Background

Unraveling the genetic background in a significant proportion of patients with both sporadic and familial IPF provided new insights into the pathogenic pathways of pulmonary fibrosis.

Aim

The aim of the present study is to overview the clinical significance of genetics in IPF.

Perspective

It is fascinating to realize the so-far underestimated but dynamically increasing impact that genetics has on aspects related to the pathophysiology, accurate and early diagnosis, and treatment and prevention of this devastating disease. Genetics in IPF have contributed as no other in unchaining the disease from the dogma of a "a sporadic entity of the elderly, limited to the lungs" and allowed all scientists, but mostly clinicians, all over the world to consider its many

SUBMITTER: Papiris SA 

PROVIDER: S-EPMC9777433 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature