Integrative Meta-Analysis of Huntington's Disease Transcriptome Landscape.

ABSTRACT: Huntington's disease (HD) is a neurodegenerative disorder with autosomal dominant inheritance caused by glutamine expansion in the Huntingtin gene (HTT). Striatal projection neurons (SPNs) in HD are more vulnerable to cell death. The executive striatal population is directly connected with the Brodmann Area (BA9), which is mainly involved in motor functions. Analyzing the disease samples from BA9 from the SRA database provides insights related to neuron degeneration, which helps to identify a promising therapeutic strategy. Most gene expression studies examine the changes in expression and associated biological functions. In this study, we elucidate the relationship between variants and their effect on gene/downstream transcript expression. We computed gene and transcript abundance and ide

SUBMITTER: Sneha NP 

PROVIDER: S-EPMC9777612 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature