Ontology highlight
ABSTRACT:
SUBMITTER: Keller CR
PROVIDER: S-EPMC9777629 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
Keller Chandler R CR Ruud Kelsey F KF Martinez Steve R SR Li Weimin W
Gels (Basel, Switzerland) 20221218 12
Modeling human breast tissue architecture is essential to study the pathophysiological conditions of the breast. We report that normal mammary epithelial cells grown in human breast extracellular matrix (ECM) hydrogel formed acini structurally similar to those of human and pig mammary tissues. Type I, II, III and V collagens were commonly identified in human, pig, and mouse breast ECM. Mammary epithelial cells formed acini on certain types or combinations of the four collagens at normal levels o ...[more]