EpiReSIM: A Resampling Method of Epistatic Model without Marginal Effects Using Under-Determined System of Equations.

ABSTRACT: Simulation experiments are essential to evaluate epistasis detection methods, which is the main way to prove their effectiveness and move toward practical applications. However, due to the lack of effective simulators, especially for simulating models without marginal effects (eNME models), epistasis detection methods can hardly verify their effectiveness through simulation experiments. In this study, we propose a resampling simulation method (EpiReSIM) for generating the eNME model. First, EpiReSIM provides two strategies for solving eNME models. One is to calculate eNME models using prevalence constraints, and another is by joint constraints of prevalence and heritability. We transform the computation of the model into the problem of solving the under-determined system of equations. Intr

SUBMITTER: Shang J 

PROVIDER: S-EPMC9777644 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature