Proteomic Markers in the Muscles and Brain of Pigs Recovered from Hemorrhagic Stroke.

ABSTRACT: (1) Background: Stroke is the leading cause of serious long-term disability. Walking dysfunction and paresis of the upper extremities occurs in more than 80% of people who have had a stroke. (2) Methods: We studied post-genomic markers in biosamples of muscle and brain tissue from animals that underwent intracerebral hematoma and recovered after 42 days. Our purpose was to understand the biological mechanisms associated with recovery from hemorrhagic stroke. We analyzed the peptides formed after trypsinolysis of samples by HPLC-MS, and the results were processed by bioinformatics methods, including the establishment of biochemical relationships (gene to gene) using topological omics databases such as Reactome and KEGG. (3) Results: In the pig brain, unique compounds were identified which a

SUBMITTER: Fedulova L 

PROVIDER: S-EPMC9777686 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature