Multiplex Tissue Imaging Harmonization: A Multicenter Experience from CIMAC-CIDC Immuno-Oncology Biomarkers Network.

ABSTRACT:

Purpose

The Cancer Immune Monitoring and Analysis Centers - Cancer Immunologic Data Commons (CIMAC-CIDC) network supported by the NCI Cancer Moonshot initiative was established to provide correlative analyses for clinical trials in cancer immunotherapy, using state-of-the-art technology. Fundamental to this initiative is implementation of multiplex IHC assays to define the composition and distribution of immune infiltrates within tumors in the context of their potential role as biomarkers. A critical unanswered question involves the relative fidelity of such assays to reliably quantify tumor-associated immune cells across different platforms.

Experimental design

Three CIMAC sites compared across their laboratories: (i) image analysis algorithms, (ii) image acquisition platfo

SUBMITTER: Akturk G 

PROVIDER: S-EPMC9777693 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature