Can Polymorphisms in NLRP3 Inflammasome Complex Be Associated with Postmenopausal Osteoporosis Severity?

ABSTRACT: The immune system plays a critical role in bone homeostasis and, consequently, in the pathophysiology of postmenopausal osteoporosis (OP) since estrogen deficiency induces the inflammasome and increases production of pro-inflammatory cytokines, such as IL-1β and IL-18. NLRP3 inflammasome complex genes have been related with bone homeostasis in cellular and animal models. Here, we performed an association study evaluating SNVs (single-nucleotide variants) in inflammasome NLRP3 pathway genes (NLRP3, CARD8, CASP1, IL-18, and IL-1β) to assess whether variants in these genes could be related to susceptibility to primary OP in postmenopausal women.

Methods

We genotyped 196 postmenopausal OP patients and 103 healthy controls using SNV-specific Taqman^® probes. Data and statistica

SUBMITTER: Guarana WL 

PROVIDER: S-EPMC9777825 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature