Sialyltransferases and Neuraminidases: Potential Targets for Cancer Treatment.

ABSTRACT: Cancers are the leading cause of death, causing around 10 million deaths annually by 2020. The most common cancers are those affecting the breast, lungs, colon, and rectum. However, it has been noted that cancer metastasis is more lethal than just cancer incidence and accounts for more than 90% of cancer deaths. Thus, early detection and prevention of cancer metastasis have the capability to save millions of lives. Finding novel biomarkers and targets for screening, determination of prognosis, targeted therapies, etc., are ways of doing so. In this review, we propose various sialyltransferases and neuraminidases as potential therapeutic targets for the treatment of the most common cancers, along with a few rare ones, on the basis of existing experimental and in silico data. This compilatio

SUBMITTER: Nag S 

PROVIDER: S-EPMC9777960 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature