The Association of Variants within Types V and XI Collagen Genes with Knee Joint Laxity Measurements.

ABSTRACT: Joint laxity is a multifactorial phenotype with a heritable component. Mutations or common polymorphisms within the α1(V) (COL5A1), α1(XI) (COL11A1) and α2(XI) (COL11A2) collagen genes have been reported or proposed to associate with joint hypermobility, range of motion and/or genu recurvatum. The aim of this study was to investigate whether polymorphisms within these collagen-encoding genes are associated with measurements of knee joint laxity and computed ligament length changes within the non-dominant leg. One hundred and six healthy participants were assessed for genu recurvatum (knee hyperextension), anterior-posterior tibial translation, external-internal tibial rotation and ligament length changes during knee rotation of their non-dominant leg. Participan

SUBMITTER: Beckley S 

PROVIDER: S-EPMC9778334 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature