MDSN: A Module Detection Method for Identifying High-Order Epistatic Interactions.

ABSTRACT: Epistatic interactions are referred to as SNPs (single nucleotide polymorphisms) that affect disease development and trait expression nonlinearly, and hence identifying epistatic interactions plays a great role in explaining the pathogenesis and genetic heterogeneity of complex diseases. Many methods have been proposed for epistasis detection; nevertheless, they mainly focus on low-order epistatic interactions, two-order or three-order for instance, and often ignore high-order interactions due to computational burden. In this paper, a module detection method called MDSN is proposed for identifying high-order epistatic interactions. First, an SNP network is constructed by a construction strategy of interaction complementary, which consists of low-order SNP interactions that can be obtained

SUBMITTER: Sun Y 

PROVIDER: S-EPMC9778340 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature