Three-Dimensional Organization of Chicken Genome Provides Insights into Genetic Adaptation to Extreme Environments.

ABSTRACT: The high-throughput chromosome conformation capture (Hi-C) technique is widely used to study the functional roles of the three-dimensional (3D) architecture of genomes. However, the knowledge of the 3D genome structure and its dynamics during extreme environmental adaptations remains poor. Here, we characterized 3D genome architectures using the Hi-C technique for chicken liver cells. Upon comparing Lindian chicken (LDC) liver cells with Wenchang chicken (WCC) liver cells, we discovered that environmental adaptation contributed to the switching of A/B compartments, the reorganization of topologically associated domains (TADs), and TAD boundaries in both liver cells. In addition, the analysis of the switching of A/B compartments revealed that the switched compartmental genes (SCGs) were str

SUBMITTER: Shao D 

PROVIDER: S-EPMC9778438 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature