Trichuris WAP and CAP proteins: Potential whipworm vaccine candidates?

ABSTRACT: Trichuris trichiura and T. suis are gastrointestinal dwelling roundworms that infect humans and pigs, respectively. Heavy infections cause gastrointestinal symptoms and impaired growth and development. Vaccination has the potential to reduce the disease burden of whipworm infection; however, there are currently no commercially available vaccines against these parasites and very few against other gastrointestinal-dwelling nematodes of medical and agricultural importance. The naturally occurring mouse whipworm, T. muris, has been used for decades to model human trichuriasis, and the immunogenic potential of the excretory/secretory material (E/S, which can be collected following ex vivo culture of worms) has been studied in the context of vaccine candidate identification. Despite this, resear

SUBMITTER: Wainwright E 

PROVIDER: S-EPMC9778506 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature