Metabolomics and Proteomics Characterizing Hepatic Reactions to Dietary Linseed Oil in Duck.

ABSTRACT: The imbalance in polyunsaturated fatty acid (PUFA) composition in human food is ubiquitous and closely related to obesity and cardiovascular diseases. The development of n-3 PUFA-enriched poultry products is of great significance for optimizing fatty acid composition. This study aimed to improve our understanding of the effects of dietary linseed oil on hepatic metabolism using untargeted metabolomics and 4D label-free proteome analysis. A total of 91 metabolites and 63 proteins showed differences in abundance in duck livers between the high linseed oil and control groups. Pathway analysis revealed that the biosynthesis of unsaturated fatty acids, linoleic acid, glycerophospholipid, and pyrimidine metabolisms were significantly enriched in ducks fed with linseed oil. Meanwhile, dietary lin

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC9778787 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature