Antibiotic Cycling Affects Resistance Evolution Independently of Collateral Sensitivity.

ABSTRACT: Antibiotic cycling has been proposed as a promising approach to slow down resistance evolution against currently employed antibiotics. It remains unclear, however, to which extent the decreased resistance evolution is the result of collateral sensitivity, an evolutionary trade-off where resistance to one antibiotic enhances the sensitivity to the second, or due to additional effects of the evolved genetic background, in which mutations accumulated during treatment with a first antibiotic alter the emergence and spread of resistance against a second antibiotic via other mechanisms. Also, the influence of antibiotic exposure patterns on the outcome of drug cycling is unknown. Here, we systematically assessed the effects of the evolved genetic background by focusing on the first switch betwee

SUBMITTER: Brepoels P 

PROVIDER: S-EPMC9778841 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature