The Assessment of Skin Homeostasis Changes after Using Different Types of Excipients in Healthy Individuals.

ABSTRACT: Excipients are used as vehicles for topical treatments; however, there are not many studies that evaluate the impact of different excipients themselves. The aim of this research is to assess skin homeostasis changes in healthy individuals after using water/oil (W/O), oil/water (O/W), Beeler base, foam and Vaseline excipients. A within-person randomized trial was conducted that included healthy individuals without previous skin diseases. Skin barrier function parameters, including stratum corneum hydration (SCH), transepidermal water loss (TEWL), pH, temperature, erythema, melanin and elasticity (R0, R2, R5 and R7), were measured on the volar forearm before and after using each excipient. Sixty participants were included in the study, with a mean age of 32 years. After applying w/o excipien

SUBMITTER: Ordonez-Toro A 

PROVIDER: S-EPMC9778961 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature