Macrophage Migration Inhibitory Factor in Major Depressive Disorder: A Multilevel Pilot Study.

ABSTRACT: Macrophage migration inhibitory factor (MIF) is a controversially discussed inflammatory marker in major depressive disorder (MDD). While some studies show an association of high MIF protein levels with depression, animal models have yielded conflicting results. Thus, it remains elusive as to whether MIF plays an anti- or pro-depressive role. Therefore, we aimed to examine the potential of MIF at the genetic, expression and protein levels as a risk factor and biomarker to diagnose, monitor, or predict the course of MDD. Patients with a current major depressive episode (n = 66 with, and n = 63 without, prior medication) and remitted patients (n = 39) were compared with healthy controls (n = 61). Currently depressed patients provided a second blood sample after th

SUBMITTER: Swoboda C 

PROVIDER: S-EPMC9779321 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature