Ontology highlight
ABSTRACT:
SUBMITTER: de Oya IG
PROVIDER: S-EPMC9779322 | biostudies-literature | 2022 Dec
REPOSITORIES: biostudies-literature
de Oya Inés G IG Jiménez-Gutiérrez Elena E Gaillard Hélène H Molina María M Martín Humberto H Wellinger Ralf Erik RE
International journal of molecular sciences 20221211 24
Understanding which intracellular signaling pathways are activated by manganese stress is crucial to decipher how metal overload compromise cellular integrity. Here, we unveil a role for oxidative and cell wall stress signaling in the response to manganese stress in yeast. We find that the oxidative stress transcription factor Yap1 protects cells against manganese toxicity. Conversely, extracellular manganese addition causes a rapid decay in Yap1 protein levels. In addition, manganese stress act ...[more]