The Ros/MucR Zinc-Finger Protein Family in Bacteria: Structure and Functions.

ABSTRACT: Ros/MucR is a widespread family of bacterial zinc-finger-containing proteins that integrate multiple functions, such as symbiosis, virulence, transcription regulation, motility, production of surface components, and various other physiological processes in cells. This regulatory protein family is conserved in bacteria and is characterized by its zinc-finger motif, which has been proposed as the ancestral domain from which the eukaryotic C₂H₂ zinc-finger structure has evolved. The first prokaryotic zinc-finger domain found in the transcription regulator Ros was identified in Agrobacterium tumefaciens. In the past decades, a large body of evidence revealed Ros/MucR as pleiotropic transcriptional regulators that mainly act as repressors through oligomerization and

SUBMITTER: Janczarek M 

PROVIDER: S-EPMC9779718 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature