Immune subtype identification and multi-layer perceptron classifier construction for breast cancer.

ABSTRACT:

Introduction

Breast cancer is a heterogeneous tumor. Tumor microenvironment (TME) has an important effect on the proliferation, metastasis, treatment, and prognosis of breast cancer.

Methods

In this study, we calculated the relative proportion of tumor infiltrating immune cells (TIICs) in the breast cancer TME, and used the consensus clustering algorithm to cluster the breast cancer subtypes. We also developed a multi-layer perceptron (MLP) classifier based on a deep learning framework to detect breast cancer subtypes, which 70% of the breast cancer research cohort was used for the model training and 30% for validation.

Results

By performing the K-means clustering algorithm, the research cohort was clustered into two subtypes. The Kaplan-Meier survival estimate analys

SUBMITTER: Yang X 

PROVIDER: S-EPMC9780074 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature