Analysis of Complex Absorption After Multiple Dosing: Application to the Interaction Between the P-glycoprotein Substrate Talinolol and Rifampicin.

ABSTRACT:

Purpose

In order to clarify the effect of rifampicin on the bioavailability of the P-glycoprotein substrate talinolol, its absorption kinetics was modeled after multiple-dose oral administration of talinolol in healthy subjects.

Methods

A sum of two inverse Gaussian functions was used to calculate the time course of the input rate into the systemic circulation.

Results

The estimated rate of drug entry into the systemic circulation revealed two distinct peaks at 1 and 3.5 h after administration. Rifampicin did not affect bioavailability of talinolol, but did shift the second peak of the input function by 1.3 h to later times. Elimination clearance and one of the intercompartmental distribution clearances increased significantly under rifampicin treatment.

Conclusion

SUBMITTER: Weiss M 

PROVIDER: S-EPMC9780127 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature