The association between gut hormones and diet-induced metabolic flexibility in metabolically healthy adults.

ABSTRACT:

Objective

This study investigated whether interindividual variance in diet-induced metabolic flexibility is explained by differences in gut hormone concentrations.

Methods

A total of 69 healthy volunteers with normal glucose regulation underwent 24-hour assessments of respiratory quotient (RQ) in a whole-room indirect calorimeter during eucaloric feeding (EBL; 50% carbohydrate, 30% fat) and then, in a crossover design, during 24-hour fasting and three normal-protein (20%) overfeeding diets (200% energy requirements). Metabolic flexibility was defined as the change in 24-hour RQ from EBL during standard (50% carbohydrate), high-fat (60%), and high-carbohydrate (75%) overfeeding diets. Plasma concentrations of glucagon-like peptide-1 (GLP-1) and peptide YY (PYY) after an overn

SUBMITTER: Unlu Y 

PROVIDER: S-EPMC9780166 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature