3D Bioprinted Patient-Specific Extracellular Matrix Scaffolds for Soft Tissue Defects.

ABSTRACT: Soft tissue injuries such as volumetric muscle loss (VML) are often too large to heal normally on their own, resulting in scar formation and functional deficits. Decellularized extracellular matrix (dECM) scaffolds placed into these wounds have shown the ability to modulate the immune response and drive constructive healing. This provides a potential solution for functional tissue regeneration, however, these acellular dECM scaffolds are challenging to fabricate into complex geometries. 3D bioprinting is uniquely positioned to address this, being able to create patient-specific scaffolds based on clinical 3D imaging data. Here, a process to use freeform reversible embedding of suspended hydrogels (FRESH) 3D bioprinting and computed tomography (CT) imaging to build large volume, patient-spe

SUBMITTER: Behre A 

PROVIDER: S-EPMC9780169 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature