Optimal Cerebral Perfusion Pressure and Brain Tissue Oxygen in Aneurysmal Subarachnoid Hemorrhage.

ABSTRACT:

Background

Targeting a cerebral perfusion pressure optimal for cerebral autoregulation (CPPopt) has been gaining more attention to prevent secondary damage after acute neurological injury. Brain tissue oxygenation (PbtO₂) can identify insufficient cerebral blood flow and secondary brain injury. Defining the relationship between CPPopt and PbtO₂ after aneurysmal subarachnoid hemorrhage may result in (1) mechanistic insights into whether and how CPPopt-based strategies might be beneficial and (2) establishing support for the use of PbtO₂ as an adjunctive monitor for adequate or optimal local perfusion.

Methods

We performed a retrospective analysis of a prospectively collected 2-center dataset of patients with aneurysmal subarachnoid hemorrhage

SUBMITTER: Megjhani M 

PROVIDER: S-EPMC9780174 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature