The number of metastatic lymph nodes optimizes staging in patients aged 55 years or older with papillary thyroid cancer

ABSTRACT:

Purpose

Current staging criteria for papillary thyroid cancer (PTC) do not include the number of metastatic lymph nodes (LNs), which is highly predictive of survival in multiple cancers. The LN metastasis burden is particularly relevant for older adults with thyroid cancer because of their poor prognosis. We examined a modified staging system for this population utilizing node number (Nn).

Methods

Overall, 14,341 patients aged 55 years or older with stage I-IVB PTC were identified in the 2004–2015 Surveillance, Epidemiology and End Results database. Cox regression models were conducted to test the relationship between positive LN number and PTC-specific survival (PTCSS). Independent training/validation sets were used to derive and validate a new revised TNnM grouping. The

SUBMITTER: Sun Y 

PROVIDER: S-EPMC9780272 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature