Caudate-anchored cognitive connectivity pursuant to orthostatic hypotension in early Parkinson's disease.

ABSTRACT: ¹⁸F-Florbetaben is a tracer used to evaluate the metabolic activity of and amyloid accumulation in the brain when measured in early- and late-phase, respectively. The metabolism of neural substrates could be viewed as a network and might be an important factor in cognition. Orthostatic hypotension (OH) might play an indirect moderating role in cognition, and its latent influence could modify the inherent cognitive network. This study aimed to identify changes of cognitive connectivity according to orthostatic stress in patients with early Parkinson's disease (PD). This study included 104 early PD patients who were evaluated with a head-up tilt-test and¹⁸F-Florbetaben positron emission tomography (PET). Cognition was assessed with a comprehensive neuropsychological bat

SUBMITTER: Yoo SW 

PROVIDER: S-EPMC9780335 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature