Exploring the common gene signatures and pathogeneses of obesity with Alzheimer's disease via transcriptome data.

ABSTRACT:

Background

Obesity is a complex condition that influences several organ systems and physiologic systems. Obesity (OB) is closely linked to Alzheimer's disease (AD). However, the interrelationship between them remains unclear. The purpose of this study is to explore the key genes and potential molecular mechanisms in obesity and AD.

Methods

The microarray data for OB and AD were downloaded from the Gene Expression Omnibus (GEO) database. Weighted gene correlation network analysis (WGCNA) was used to delineate the co-expression modules related to OB and AD. The shared genes existing in obesity and AD were identified through biological process analyses using the DAVID website, which then constructed the Protein-Protein Interaction (PPI) Network and selected the hub genes by Cyt

SUBMITTER: Li T 

PROVIDER: S-EPMC9780446 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature