Prediction of bronchodilation test in adults with chronic cough suspected of cough variant asthma.

ABSTRACT:

Background

Many patients with cough variant asthma (CVA) are underdiagnosed and undertreated due to the atypical symptoms, low diagnostic sensitivity of bronchodilator response (BDR), and limited application of bronchial challenge test.

Objective

To investigate whether airway reversibility in BDR can predict CVA diagnosis in patients with chronic cough and negative BDR.

Methods

This open-label, prospective cohort study included patients with chronic cough, nearly normal chest CT scan, and negative BDR results. Inhaled corticosteroids and long-acting β₂ agonists were given for 4 weeks. The confirmed diagnosis of CVA was defined as improved symptoms and an increase of forced expiratory volume in 1 s (FEV₁) by >12% and >200 mL after 4 weeks of treat

SUBMITTER: Hao H 

PROVIDER: S-EPMC9780531 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature