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Profiling of Urinary Glucuronidated Bile Acids across Age Groups.

ABSTRACT: We investigated the age-dependent changes in urinary excretion of glucuronidated bile acids at the C-3 position. Bile acid 3-glucuronides accounted for 0.5% of urinary bile acids in neonates, and the proportion of bile acid 3-glucuronides plateaued at 1-3 years of age. The 3-glucuronides of secondary bile acids were first secreted at 3 months of age, the same time as the establishment of the gut bacterial flora in infants. A considerable portion of bile acid 3-glucuronides were present as non-amidated forms. Our results indicate dynamic hepatic enzyme activity in which the levels of uridine 5'-diphospho-glucuronosyltransferases (UGTs) differ by age group, with higher glucuronidation activity of UGTs towards nonamidated bile acids than amidated bile acids.

SUBMITTER: Muto Y

PROVIDER: S-EPMC9780789 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature

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Profiling of Urinary Glucuronidated Bile Acids across Age Groups.

Muto Yamato Y Suzuki Mitsuyoshi M Kakiyama Genta G Sasaki Takahiro T Murai Tsuyoshi T Takei Hajime H Nittono Hiroshi H

Metabolites 20221207 12

We investigated the age-dependent changes in urinary excretion of glucuronidated bile acids at the C-3 position. Bile acid 3-glucuronides accounted for 0.5% of urinary bile acids in neonates, and the proportion of bile acid 3-glucuronides plateaued at 1-3 years of age. The 3-glucuronides of secondary bile acids were first secreted at 3 months of age, the same time as the establishment of the gut bacterial flora in infants. A considerable portion of bile acid 3-glucuronides were present as non-am ...[more]

PMID: 36557268

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