Copper-Catalyzed Asymmetric Sulfonylative Desymmetrization of Glycerol.

ABSTRACT: Glycerol is the main side product in the biodiesel manufacturing process, and the development of glycerol valorization methods would indirectly contribute the sustainable biodiesel production and decarbonization. Transformation of glycerol to optically active C3 units would be one of the attractive routes for glycerol valorization. We herein present the asymmetric sulfonylative desymmetrization of glycerol by using a CuCN/(R,R)-PhBOX catalyst system to provide an optically active monosulfonylated glycerol in high efficiency. A high degree of enantioselectivity was achieved with a commercially available chiral ligand and an inexpensive carbonate base. The optically active monosulfonylated glycerol was successfully transformed into a C3 unit attached with differentially protect

SUBMITTER: Yamamoto K 

PROVIDER: S-EPMC9780796 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature