Therapeutic Potentials of Immunometabolomic Modulations Induced by Tuberculosis Vaccination.

ABSTRACT: Metabolomics is emerging as a promising tool to understand the effect of immunometabolism for the development of novel host-directed alternative therapies. Immunometabolism can modulate both innate and adaptive immunity in response to pathogens and vaccinations. For instance, infections can affect lipid and amino acid metabolism while vaccines can trigger bile acid and carbohydrate pathways. Metabolomics as a vaccinomics tool, can provide a broader picture of vaccine-induced biochemical changes and pave a path to potentiate the vaccine efficacy. Its integration with other systems biology tools or treatment modes can enhance the cure, response rate, and control over the emergence of drug-resistant strains. Mycobacterium tuberculosis (Mtb) infection can remodel the host metabol

SUBMITTER: Rawat BS 

PROVIDER: S-EPMC9781011 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature