Plasma Concentrations of Short-Chain Fatty Acids in Active and Recovered Anorexia Nervosa.

ABSTRACT: Anorexia nervosa (AN) is one of the most lethal psychiatric disorders. To date, we lack adequate knowledge about the (neuro)biological mechanisms of this disorder to inform evidence-based pharmacological treatment. Gut dysbiosis is a trending topic in mental health, including AN. Communication between the gut microbiota and the brain is partly mediated by metabolites produced by the gut microbiota such as short-chain fatty acids (SCFA). Previous research has suggested a role of SCFA in weight regulation (e.g., correlations between specific SCFA-producing bacteria and BMI have been demonstrated). Moreover, fecal SCFA concentrations are reported to be altered in active AN. However, data concerning SCFA concentrations in individuals who have recovered from AN are limited. In the present study

SUBMITTER: Xu J 

PROVIDER: S-EPMC9781195 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature