Synthesis of Dipyridylaminoperylenediimide-Metal Complexes and Their Cytotoxicity Studies.

ABSTRACT: A new family of perylenediimide (PDI) silver and copper complexes has been successfully synthesized by reacting ortho- and bay-substituted (dipyrid-2',2″-ylamino)perylenediimide ligands with metal phosphine fragments. The coordination of the metal center did not reveal a significant effect on the photophysical properties, which are mainly due to the PDI ligands, and in some cases quenching of the luminescence was observed. The antiproliferative effect of the free perylenediimide ligands and the metalloPDI complexes against the cervix cancer cell line HeLa was determined by MTT assay. The free perylenediimide ligands exhibited a moderate cytotoxic activity, but the coordination of silver or copper to the dypyridylamino fragment greatly enhanced the activity, suggesting a syner

SUBMITTER: Garces-Garces J 

PROVIDER: S-EPMC9781374 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature