Clinical and Safety Outcomes Associated with Extended Treatment of Venous Thromboembolism: A Network Meta-Analysis.

ABSTRACT:

Background

Many anticoagulant strategies are available for the extended treatment of venous thromboembolism, yet little guidance exists regarding which drug is most effective and safe.

Aim

A network meta-analysis was performed to resolve this uncertainty.

Methods

We searched the medical literature through June 2022 for randomized controlled trials (RCTs) evaluating the efficacy and safety of anticoagulants for adults with VTE compared with other anticoagulants or a placebo.

Results

We identified 13 eligible RCTs in 12 articles. All pooled hazard ratios (HR) and 95% credible intervals (CrI) mentioned below, except that for aspirin, were calculated by comparison with standard-intensity warfarin. Novel oral anticoagulants (NOACs) were not inferior to standard-inte

SUBMITTER: Liu Z 

PROVIDER: S-EPMC9781418 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature