IL-10-Secreting CD8⁺ T Cells Specific for Human Cytomegalovirus (HCMV): Generation, Maintenance and Phenotype.

ABSTRACT: HCMV-specific CD8⁺ T-cells are potent anti-viral effector cells in HCMV infected individuals, but evidence from other viral infections suggests that CD8⁺ T-cells can also produce the immunomodulatory cytokine IL-10. In this work we show that there are HCMV-specific IL-10 CD8⁺ T-cell responses in a cohort of individuals aged 23-76 years of age, predominantly directed against the HCMV proteins known to be expressed during latent infections as well as towards the proteins US3 and pp71. The analysis of HCMV-specific responses established during primary infection has shown that the IL-10 responses to US3 and pp71 HCMV proteins are detectable in the first weeks post infection, but not the responses to latency-associated proteins, and this IL-10 response is produc

SUBMITTER: Jackson SE 

PROVIDER: S-EPMC9781655 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature