Impact of N-Linked Glycosylation on Therapeutic Proteins.

ABSTRACT: Therapeutic proteins have unique advantages over small-molecule drugs in the treatment of various diseases, such as higher target specificity, stronger pharmacological efficacy and relatively low side effects. These advantages make them increasingly valued in drug development and clinical practice. However, although highly valued, the intrinsic limitations in their physical, chemical and pharmacological properties often restrict their wider applications. As one of the most important post-translational modifications, glycosylation has been shown to exert positive effects on many properties of proteins, including molecular stability, and pharmacodynamic and pharmacokinetic characteristics. Glycoengineering, which involves changing the glycosylation patterns of proteins, is therefore expected

SUBMITTER: Chen B 

PROVIDER: S-EPMC9781892 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature