Anti-Psoriatic Effect of Rheum palmatum L. and Its Underlying Molecular Mechanisms.

ABSTRACT: Psoriasis is a chronic, immune-mediated inflammatory skin disorder. Rheum palmatum L. is a common traditional medicinal herb with anti-inflammatory and immunomodulatory activities. This study aimed to investigate the anti-psoriatic effects of the ethanolic extract from R. palmatum L. (RPE) and its chemical constituents, as well as the mechanisms underlying their therapeutic significance. An imiquimod (IMQ)-induced psoriasis-like mouse model was used to examine the anti-psoriatic effect of RPE in vivo. Network pharmacological analysis was performed to investigate the potential targets and related pathways of the RPE components, including rhein, emodin, chrysophanol, aloe-emodin, and physcion. The anti-inflammatory effects and underlying mechanisms of these components were exam

SUBMITTER: Nguyen LTH 

PROVIDER: S-EPMC9781959 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature