The Biomimetic System of Oleanolic Acid and Oleic Acid at the Air-Water Interface-Interactions in Terms of Nanotechnology-Based Drug Delivery Systems.

ABSTRACT: Oleanolic acid (OLA) and oleic acid (OA) are ubiquitous in the plant kingdom, exhibiting a therapeutic effect on human health, and are components of novel pharmaceutical formulations. Since OLA has limited solubility, the utilization of nanotechnology-based drug delivery systems enhancing bioavailability is highly advantageous. We report on the interfacial behavior of the OLA:OA system at various molar ratios, using the Langmuir technique to assess the dependence of the molar composition on miscibility and rheological properties affecting film stability. Specifically, we evaluate the interfacial properties (morphology, thermodynamics, miscibility, and viscoelasticity) of the OLA:OA binary system in various molar ratios, and indicate how the OLA:OA system exhibits the most favorable molecul

SUBMITTER: Krajewska M 

PROVIDER: S-EPMC9782233 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature