Integracides: Tetracyclic Triterpenoids from Fusarium sp.-Their 5-Lipoxygenase Inhibitory Potential and Structure-Activity Relation Using In Vitro and Molecular Docking Studies.

ABSTRACT: Inflammation is a complicated disorder that is produced as a result of consecutive processes. 5-LOX (5-lipoxygenase) is accountable for various inflammation mediators and leukotrienes synthesis, and its inhibition is the target of anti-inflammation therapeutics. Fungi have acquired enormous attentiveness because of their capability to biosynthesize novel bio-metabolites that reveal diversified bio-activities. A new tetracyclic triterpenoid, integracide L (1), along with integracides B (2) and F (3), were separated from Mentha longifolia-associated Fusarium sp. (FS No. MAR2014). Their structures were verified utilizing varied spectral analyses. The isolated metabolites (1-3), alongside the earlier reported integracides G (4), H (5</

SUBMITTER: Khayat MT 

PROVIDER: S-EPMC9782297 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature