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Clickable C-Glycosyl Scaffold for the Development of a Dual Fluorescent and [¹⁸F]fluorinated Cyanine-Containing Probe and Preliminary In Vitro/Vivo Evaluation by Fluorescence Imaging.

ABSTRACT: Considering the individual characteristics of positron emission tomography (PET) and optical imaging (OI) in terms of sensitivity, spatial resolution, and tissue penetration, the development of dual imaging agents for bimodal PET/OI imaging is a growing field. A current major breakthrough in this field is the design of monomolecular agent displaying both a radioisotope for PET and a fluorescent dye for OI. We took advantage of the multifunctionalities allowed by a clickable C-glycosyl scaffold to gather the different elements. We describe, for the first time, the synthesis of a cyanine-based dual PET/OI imaging probe based on a versatile synthetic strategy and its direct radiofluorination via [¹⁸F]F-C bond formation. The non-radioactive dual imaging probe coupled with two

SUBMITTER: Ariztia J

PROVIDER: S-EPMC9782470 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature

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Dataset Information

Clickable C-Glycosyl Scaffold for the Development of a Dual Fluorescent and [¹⁸F]fluorinated Cyanine-Containing Probe and Preliminary In Vitro/Vivo Evaluation by Fluorescence Imaging.

OmicsDI is part of the ELIXIR infrastructure

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Dataset Information

Clickable C-Glycosyl Scaffold for the Development of a Dual Fluorescent and [18F]fluorinated Cyanine-Containing Probe and Preliminary In Vitro/Vivo Evaluation by Fluorescence Imaging.

OmicsDI is part of the ELIXIR infrastructure

Tweets

Clickable C-Glycosyl Scaffold for the Development of a Dual Fluorescent and [¹⁸F]fluorinated Cyanine-Containing Probe and Preliminary In Vitro/Vivo Evaluation by Fluorescence Imaging.