Fat content in infant mesenchymal stem cells prospectively associates with childhood adiposity and fasting glucose.

ABSTRACT:

Objective

In human studies, new model systems are needed for improved mechanistic investigation of developmental predisposition for metabolic disease but also to serve as benchmarks in early life prevention or intervention efforts. In this regard, human infant umbilical cord-derived mesenchymal stem cells (MSCs) are an emerging tool. However, long-term clinical relevance to in vivo markers of metabolic disease is unknown.

Methods

In a cohort of 124 mother/child dyads, this study tested the hypothesis that triglyceride content (TG) of infant MSCs undergoing adipogenesis in vitro (MSC-TG) is associated with in vivo adiposity (percent fat mass) from birth to early childhood and with fasting glucose and insulin in early childhood.

Results

MSC-TG was positively associated

SUBMITTER: Gyllenhammer LE 

PROVIDER: S-EPMC9782692 | biostudies-literature | 2023 Jan

REPOSITORIES: biostudies-literature