Epigallocatechin Gallate and Glutathione Attenuate Aflatoxin B₁-Induced Acute Liver Injury in Ducklings via Mitochondria-Mediated Apoptosis and the Nrf2 Signalling Pathway.

ABSTRACT: Aflatoxin B₁ (AFB₁) exists widely in feed and food with severe hazards, posing a serious threat to human and animal health. Epigallocatechin gallate (EGCG) and glutathione (GSH) have been reported as having anti-oxidative and other functions. The present study aimed to investigate the detoxification effect of EGCG and GSH alone or in combination on AFB₁ exposure in ducklings. Fifty one-day-old male ducklings were randomly assigned into five experimental groups (n = 10): 1. Control (CTR); 2. 0.3 mg/kg BW AFB₁ (AFB₁); 3. 0.3 mg/kg BW AFB₁ + 100 mg/kg BW EGCG (AFB₁ + EGCG); 4. 0.3 mg/kg BW AFB₁ + 30 mg/kg BW GSH (AFB₁ + GSH); 5. 0.3 mg/kg BW AFB₁ + 100 mg/kg BW EGCG + 30 mg/kg

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9782748 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature