Reversion of Ceftazidime Resistance in Pseudomonas aeruginosa under Clinical Setting.

ABSTRACT: Pseudomonas aeruginosa is an important nosocomial pathogen which frequently becomes resistant to most antibiotics used in chemotherapy, resulting in treatment failure among infected individuals. Although the evolutionary trajectory and molecular mechanisms for becoming β-lactam resistant have been well established for P. aeruginosa, the molecular basis of reversion from β-lactam resistant to susceptible is largely unexplored. In this study, we investigated the molecular mechanisms by which a ceftazidime-resistant clinical strain is converted to a ceftazidime-susceptible isolate under the clinical setting. RNA sequencing and genomic DNA reference mapping were conducted to compare the transcriptional profiles and chromosomal mutations between these two isolates. Our results dem

SUBMITTER: Liu Q 

PROVIDER: S-EPMC9782964 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature