Advances and Challenges of Cannabidiol as an Anti-Seizure Strategy: Preclinical Evidence.

ABSTRACT: The use of Cannabis for medicinal purposes has been documented since ancient times, where one of its principal cannabinoids extracted from Cannabis sativa, cannabidiol (CBD), has emerged over the last few years as a promising molecule with anti-seizure potential. Here, we present an overview of recent literature pointing out CBD's pharmacological profile (solubility, metabolism, drug-drug interactions, etc.,), CBD's interactions with multiple molecular targets as well as advances in preclinical research concerning its anti-seizure effect on both acute seizure models and chronic models of epilepsy. We also highlight the recent attention that has been given to other natural cannabinoids and to synthetic derivatives of CBD as possible compounds with therapeutic anti-seizure potential.

SUBMITTER: Zavala-Tecuapetla C 

PROVIDER: S-EPMC9783044 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature