Total fertilization failure with in vitro fertilization-intracytoplasmic sperm injection related to WEE2 mutation highlights emerging importance of genetic causes of in vitro fertilization failure.

ABSTRACT:

Objective

To report a unique case of total fertilization failure (TFF) after in vitro fertilization with intracytoplasmic sperm injection related to homozygous WEE2 gene mutation and summarize the current literature and management of TFF.

Design

Case report.

Setting

Academic fertility center.

Patients

A 25-year-old woman and her 35-year-old partner with a history of near-complete fertilization failure after 2 cycles of in vitro fertilization/intracytoplasmic sperm injection.

Interventions

Consultation with medical and commercial genetic testing for WEE2, PLCZ1, and TLE6.

Main outcome measures

Oocyte fertilization.

Results

The patient was homozygous for WEE2 pathogenic variant impacting oocyte activation an

SUBMITTER: Weiner HS 

PROVIDER: S-EPMC9783144 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature