Using a Material Library to Understand the Change of Tabletability by High Shear Wet Granulation.

ABSTRACT: Understanding the tabletability change of materials after granulation is critical for the formulation and process design in tablet development. In this paper, a material library consisting of 30 pharmaceutical materials was used to summarize the pattern of change of tabletability during high shear wet granulation and tableting (HSWGT). Each powdered material and the corresponding granules were characterized by 19 physical properties and nine compression behavior classification system (CBCS) parameters. Principal component analysis (PCA) was used to compare the physical properties and compression behaviors of ungranulated powders and granules. A new index, namely the relative change of tabletability (CoT_r), was proposed to quantify the tabletability change, and its advanta

SUBMITTER: Wang Y 

PROVIDER: S-EPMC9783360 | biostudies-literature | 2022 Nov

REPOSITORIES: biostudies-literature