The new insight into the inflammatory response following focused ultrasound-mediated blood-brain barrier disruption.

ABSTRACT:

Background

Despite the great potential of FUS-BBB disruption (FUS-BBBD), it is still controversial whether FUS-BBBD acts as an inducing factor of neuro-inflammation or not, and the biological responses after FUS-BBBD triggers the inflammatory process are poorly understood. The aim of this study is to investigate the safety window for FUS levels based on a comprehensive safety assessment.

Methods

The mice were treated with two different ultrasound parameters (0.25 MPa and 0.42 MPa) in the thalamus region of brain. The efficacy of BBB opening was verified by dynamic contrast-enhanced MRI (DCE-MRI) and the cavitation monitoring. The transcriptome analysis was performed to investigate the molecular response for the two BBBD conditions after FUS-mediated BBB opening in time-depen

SUBMITTER: Choi HJ 

PROVIDER: S-EPMC9783406 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature