Evolutionary trade-offs associated with copy number variations in resistance alleles in Culex pipiens mosquitoes.

ABSTRACT: Organophosphate and carbamate insecticides have largely been used worldwide to control mosquito populations. As a response, the same amino acid substitution in the ace-1 gene (G119S), conferring resistance to both insecticides, has been selected independently in many mosquito species. In Anopheles gambiae, it has recently been shown that the G119S mutation is actually part of homogeneous duplications that associate multiple resistance copies of the ace-1 gene. In this study, we showed that duplications of resistance copies of the ace-1 gene also exist in the Culex pipiens species complex. The number of copies is variable, and different numbers of copies are associated with different phenotypic trade-offs: we used a combination of bioassays and competition in population cages to show that h

SUBMITTER: Milesi P 

PROVIDER: S-EPMC9783466 | biostudies-literature | 2022 Dec

REPOSITORIES: biostudies-literature