Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19.

ABSTRACT: Coronavirus disease 2019 (COVID-19) is especially severe in aged populations¹. Vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are highly effective, but vaccine efficacy is partly compromised by the emergence of SARS-CoV-2 variants with enhanced transmissibility². The emergence of these variants emphasizes the need for further development of anti-SARS-CoV-2 therapies, especially for aged populations. Here we describe the isolation of highly virulent mouse-adapted viruses and use them to test a new therapeutic drug in infected aged animals. Many of the alterations observed in SARS-CoV-2 during mouse adaptation (positions 417, 484, 493, 498 and 501 of the spike protein) also arise in humans in variants of concern². Their appearan

SUBMITTER: Wong LR 

PROVIDER: S-EPMC9783543 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature